Flexible Fabrication and Hybridization of Bioactive Hydrogels with Robust Osteogenic Potency

Osteogenic scaffolds reproducing the natural bone composition, structures, and properties have represented possible frontier of artificially orthopedic implants with great potential to revolutionize surgical strategies against bone-related diseases. However, it is difficult achieve an all-in-one formula simultaneous requirement favorable biocompatibility, flexible adhesion, high mechanical strength, osteogenic effects. Here in this work, hydrogel scaffold fabricated by inorganic-in-organic integration between amine-modified bioactive glass (ABG) nanoparticles poly(ethylene glycol) succinimidyl glutarate-polyethyleneimine (TSG-PEI) network was introduced as tool flexibly adhere onto defective tissue subsequently accelerate formation. Since N-hydroxysuccinimide (NHS)-ester tetra-PEG-SG polymer could quickly react NH2-abundant polyethyleneimine (PEI) ABG moieties, TSG-PEI@ABG rapidly formed tailorable structures properties. Relying on dense TSG-PEI moieties a nano-scale level, expressed powerful adhesion well durable stability for engineered scaffolds. Therefore, its self-endowed adhesive compressive modulus, potency enabled prominent capacities modulation marrow mesenchymal stem cell (BMSCs) proliferation differentiation, which may propose strategy fixation regeneration promotion engineering fields.